Background: Primary Hyperoxaluria Type 1 (PH1) is an inborn error of metabolism caused by mutations in the AGXT gene, which encodes for the hepatocyte-specific enzyme alanine: glyoxylate aminotransferase (AGT).AGT catalyzes the conversion of glyoxylate to glycine in the peroxisome and prevents the build-up of oxalate which occurs in PH1.This causes
BACKGROUND: Extensive mononuclear cell infiltration is strongly correlated with liver damage in patients with chronic hepatitis B virus (CHB) infection.Macrophages and infiltrating monocytes also participate in the development of liver damage and fibrosis in animal models.However, mr robot sticker little is known regarding the immunopathogenic role
Mucinous appendiceal tumors are uncommon and include a wide spectrum of tumors whose classification remained controversial.Some of these mucin producing appendiceal tumors can disseminate to the peritoneal cavity leading to pseudomyxoma peritonei (PMP).Despite several attempts to classify mucinous tumors of appendix and PMP by different authors in
Improvements in technology have made it possible to conduct genome-wide association mapping at costs within reach of academic investigators, and experiments are currently being conducted with a variety of high-throughput platforms.To provide an appropriate context for interpreting results of such studies, we summarize here results of an investigati